Hericium Erinaceus

The Science: Hericium Erinaceus (Lion's Mane)

  • Lion’s Mane mycelium gives you wisdom. The science is in! Lion’s Mane mycelium is potent in “NGF.” A recent study showed Erinacine D, a compound produced by Lion’s Mane mycelium, stimulated Nerve Growth Factor “NGF” synthesis activity. [1] Nerve Growth Factors grow neurons and improve the function of the nervous system. Because of its anti-inflammatory properties and promotion of nerve growth factor gene expression and neurite (axon or dendrite) outgrowth, H. Erinaceus mycelium shows excellent promise for treating Alzheimer’s and Parkinson’s diseases. [2] Kiss depression goodbye? Evidence shows the possibility of Lion’s Mane Mycelium producing antidepressant-like effects. [3]

These statements have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure or prevent any disease.


[1] Hirokazu Kawagishi,, Atsushi Simada,, Kazue Shizuki,, Fumihiro Ojima,, Hironobu Mori,, Kenji Okamoto,, Hideki Sakamoto, and Shoei Furukawa, (01 Feb 1996), ERINACINE D, A STIMULATOR OF NGF-SYNTHESIS, FROM THE MYCELIA OF HERICIUM ERINACEUM, Heterocyclic Communications, Volume 2: Issue 1, P. 51-54,https://www.degruyter.com/view/journals/hc/2/1/article-p51.xml

[2] Kevin Spelman, PhD, MCPP, Elizabeth Sutherland, ND, Aravind Bagade, MD, (2017). Neurological Activity of Lion’s Mane, Journal of Restorative Medicine 2017; 6: page 19-26,

[3] Chiu, C.-H.; Chyau, C.-C.; Chen, C.-C.; Lee, L.-Y.; Chen, W.-P.; Liu, J.-L.; Lin, W.-H.; Mong, M.-C. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. Int. J. Mol. Sci. 2018, 19, 341.

[4] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. International Journal of Medicinal Mushrooms, 17(7), pp.609–618.

[5] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. Experimental and Therapeutic Medicine, 12(1), pp.513–517.