The Science: Grifola Frondosa (Maitake)

Grifola Frondosa Maitake is a widely consumed edible and medicinal fungus; Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers. Over the past three decades, G. frondosa polysaccharides were shown to possess various promising bioactivities, such as antitumor, immunomodulation, anti-oxidation, and anti-hyperglycemia. Meanwhile, they can effectively act on the skin and hematopoietic stem cells. [1] Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats. [2]
grifola frondosa

These statements have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure or prevent any disease.


[1] He, X., Wang, X., Fang, J., Chang, Y., Ning, N., Guo, H., … Zhao, Z. (2017, March 31). Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review. Retrieved from

[2] Chen, Y.-H., Lee, C.-H., Hsu, T.-H., & Lo, H.-C. (n.d.). Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function. Retrieved from,52f67ca6221cc3fa,3a1865d852b0a11c.html

[3] Wang, L., Cheng, T. L., Cheng, S. Y., Lian, T. W., & Wu, M. J. (2010, February 18). Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice. Retrieved from