Flammulina velutipes is a medicinal fungus belonging to the class Basidiomycetes with a high medicinal therapeutic value.  Many studies have demonstrated that Flammulina velutipes has various biological activities, including heptatic protection, anti-tumor and immunomodulatory activities. In the present study, one new water-soluble heteropolysaccharide, Flammulina velutipes polysaccharide I-A (FVP I-A), was extracted and purified from the medicinal fungus Flammulina velutipes using DEAE-cellulose column chromatography and Sephacryl S-300HR column chromatography. The antioxidant activity of FVP I-A was evaluated by examining its ability to scavenge superoxide and hydroxyl radicals and its reducing power. The immunomodulatory activity of FVP I-A was evaluated by measurement of nitric oxide (NO) and cytokines released and secreted by macrophages that were activated by incubation with this polysaccharide as part of the innate immune response, and determination of lymphocyte proliferation as part of the adaptive immune response. This Flammulina velutipes polysaccharide may prove useful in oxidation and immune applications. [1-4]
*These statements have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure or prevent any disease.
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